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This methylation profile is currently acquired at the MBL stage3 and remains relatively secure eventually. Nevertheless, some CLL have intratumor variability in specific regions, which can change the expression of numerous genes and aid tumor evolution.seventy one Of Take note, this variability is larger in U-CLL than in M-CLL and it is linked to rising number of subclones.7,seventy one

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Some degree of immunophenotype overlap among CLL, marginal zone lymphoma, and lymphoplasmacytic lymphoma exists. In case the analysis is unsure based on peripheral blood flow cytometry, lymph node biopsy should be pursued.

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